Side effects and Risks of tamoxifen
Tamoxifen acts like an anti-estrogen in some tissues and acts like estrogen in other tissues.
- Hot flashes and night sweats
- Cancer of the uterus (most were endometrial cancer, a few were uterine sarcoma). The risk is not present in those patients who have had a hysterectomy.
- Blood clots (DVT, PE, and stroke)
Tamoxifen is contraindicated in patients who continue to smoke due to the increased risk of thromboembolic disease.