Locally Advanced Breast Cancer
Stage (grade) III Breast Cancer
An example would be a 6 cm breast mass diagnosed as infiltrating ductal carcinoma with spread to lymph nodes. (T3 N1 Mx)
- Tumor is larger than 5 cm with positive spread to axillary lymph nodes, but the lymph nodes aren’t attached to each other. Stage IIIA.
- Tumor is smaller than 5 cm with positive spread of lymph nodes growing into each other and surrounding tissue. Stage IIIA.
- Tumor is smaller than 5 cm, but the cancer has spread to lymph nodes above the collar bone. Stage IIIB.
- Inflammatory breast cancer is considered stage IIIB breast cancer.
Treatment of locally advanced breast cancer
Neoadjuvant therapy is a historical term. Now called primary systemic therapy. This is giving chemotherapy prior to operation.
Workup includes bone scan and abdominal CT prior to initiating chemotherapy.