{"id":69,"date":"2013-09-17T00:04:37","date_gmt":"2013-09-17T00:04:37","guid":{"rendered":"http:\/\/www.breastguide.com\/breastcancerblog\/?p=69"},"modified":"2013-09-17T00:09:29","modified_gmt":"2013-09-17T00:09:29","slug":"is-there-a-difference-between-brca-1-and-brca-2","status":"publish","type":"post","link":"http:\/\/www.breastguide.com\/breastcancerblog\/is-there-a-difference-between-brca-1-and-brca-2\/","title":{"rendered":"Is there a difference between BRCA 1 and BRCA 2?"},"content":{"rendered":"<h2>BRCA are breast cancer genes<\/h2>\n<p>When working properly these are tumor supressors. \u00a0They protect against breast cancer.<\/p>\n<p>But when they are abnormal and genetically inherited &#8211; these are called the BRCA1 and BRCA2 genetic mutations.<\/p>\n<h3>Both BRCA mutations (1 and 2) increase risk of breast cancer<\/h3>\n<p>Normally women have a 12 % lifetime risk of developing breast cancer. \u00a0Having a BRCA mutation raises the risk to 50-85% with a high likelihood for a recurrence or a second tumor.\u00a0Risk is the same for BRCA1 or BRCA2<\/p>\n<p>The differences are the risks of associated other cancers.<\/p>\n<h3>Both have the increased risk of ovarian and pancreatic cancers<\/h3>\n<h4>BRCA1 mutations may have additional risk of these cancers<\/h4>\n<ul>\n<li>cervical<\/li>\n<li>uterine<\/li>\n<li>pancreatic<\/li>\n<li>colon cancer<\/li>\n<\/ul>\n<h4>BRCA2 mutations may have additional risk of these cancers<\/h4>\n<ul>\n<li>pancreatic<\/li>\n<li>stomach<\/li>\n<li>gallbladder<\/li>\n<li>bile duct<\/li>\n<li>melanoma<\/li>\n<\/ul>\n<p>Future research will discover more differences between BRCA1 and BRCA2.<\/p>\n<p>More info about <a href=\"http:\/\/www.surgerytoday.com\/education\/brca-mastectomy-angelina-jolie-and-my-thoughts-as-a-general-surgeon-in-modesto-ca\/\">BRCA mutations and Angelina Jolie<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>BRCA are breast cancer genes When working properly these are tumor supressors. \u00a0They protect against breast cancer. But when they are abnormal and genetically inherited &#8211; these are called the BRCA1 and BRCA2 genetic mutations. Both BRCA mutations (1 and 2) increase risk of breast cancer Normally women have a 12 % lifetime risk of &hellip; <a href=\"http:\/\/www.breastguide.com\/breastcancerblog\/is-there-a-difference-between-brca-1-and-brca-2\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Is there a difference between BRCA 1 and BRCA 2?<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[88,42,3],"tags":[],"class_list":["post-69","post","type-post","status-publish","format-standard","hentry","category-brca1","category-brca2","category-breast-cancer"],"_links":{"self":[{"href":"http:\/\/www.breastguide.com\/breastcancerblog\/wp-json\/wp\/v2\/posts\/69","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.breastguide.com\/breastcancerblog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.breastguide.com\/breastcancerblog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.breastguide.com\/breastcancerblog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.breastguide.com\/breastcancerblog\/wp-json\/wp\/v2\/comments?post=69"}],"version-history":[{"count":1,"href":"http:\/\/www.breastguide.com\/breastcancerblog\/wp-json\/wp\/v2\/posts\/69\/revisions"}],"predecessor-version":[{"id":70,"href":"http:\/\/www.breastguide.com\/breastcancerblog\/wp-json\/wp\/v2\/posts\/69\/revisions\/70"}],"wp:attachment":[{"href":"http:\/\/www.breastguide.com\/breastcancerblog\/wp-json\/wp\/v2\/media?parent=69"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.breastguide.com\/breastcancerblog\/wp-json\/wp\/v2\/categories?post=69"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.breastguide.com\/breastcancerblog\/wp-json\/wp\/v2\/tags?post=69"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}